3 findings behind this formula. Hover a card for the detail and the source.
Berberine lowered HbA1c, fasting and post-meal glucose and improved insulin resistance and blood lipids in adults with type 2 diabetes.
Meta-analysis of 46 RCTs in adults with type 2 diabetes, using berberine alone or with standard diabetes treatment. HbA1c fell by 0.73 percentage points, with reductions in fasting and 2-hour glucose, HOMA-IR, triglycerides and cholesterol.
In adults with prediabetes, cinnamon kept fasting glucose stable over 12 weeks while it rose with placebo, and improved glucose tolerance.
Double-blind RCT, 54 adults with prediabetes taking 500 mg cinnamon three times daily or placebo for 12 weeks. The between-group difference in fasting glucose was 5 mg/dL; 2-hour glucose and glucose area under the curve fell from baseline with cinnamon.
In adults with metabolic syndrome, Gymnema sylvestre 600 mg daily reduced body weight, BMI and VLDL over 12 weeks.
Double-blind RCT in 24 adults with metabolic syndrome taking 300 mg Gymnema sylvestre twice daily or placebo for 12 weeks. Body weight fell from 81.3 to 77.9 kg, with significant falls in BMI and VLDL.