A plant flavonoid found in strawberries and apples.
Why it’s used: A flavonoid antioxidant studied for its role in healthy ageing.
Fisetin is a flavonoid, one of the large family of plant compounds that give fruit and vegetables their colour and help protect plants from stress. It is a flavonoid antioxidant, closely related in structure to quercetin, and is studied for its role in healthy ageing.
Strawberries are the richest common food source, with around 160 micrograms per gram of fresh fruit. Apples, persimmons, grapes and onions contain smaller amounts, and cucumber is often listed too. Even a generous bowl of strawberries supplies a few milligrams, far below the amounts used in research. Supplements are plant extracts concentrated to provide far more fisetin than food, usually in capsules.
Fisetin attracted interest after a 2018 study in mice found it reduced markers of senescent cells, older cells that stop dividing but linger in tissues. These are animal findings, and they do not show the same happens in people. Human trials are now testing fisetin in older adults under medical supervision, and their results will tell us much more.
The finding behind this ingredient. Hover a card for the detail and the source.
A 12-week randomised trial in 44 men with obesity compared placebo, fisetin 200 mg a day, exercise training, or training plus fisetin. IL-6 and TNF-alpha fell in the fisetin-only group, and fasting glucose, insulin and insulin resistance fell in all active groups.
Can't see yours? Ask our team, answered within a working day.
Strawberries are the richest common source, at around 160 micrograms per gram. Apples, persimmons, grapes, onions and cucumbers contain smaller amounts. Food intake is much lower than the amounts used in research, but these foods are worth eating for many reasons.
Senolytic describes compounds that may help clear senescent cells, older cells that have stopped dividing but remain in tissues. In 2018, researchers reported this effect for fisetin in mice. Whether it happens in people is still being investigated in clinical trials.
Not much yet. Most findings come from lab and animal studies. Several clinical trials, including the AFFIRM studies in older adults, are testing fisetin under medical supervision. Until results are published, its effects in people remain unknown.
Videos from doctors, research scientists and registered dietitians, for general education. They are independent of Nutra Formulations, do not refer to our products and are not medical advice for you.
Natural Senolytics Explained: Fisetin and Quercetin for Anti-Aging
Dr Adam Sewell, MD · Dr. Adam Sewell, M.D. | Medical Entrepreneur on YouTube
Information only, not medical advice. If you take medication, are pregnant or breastfeeding, speak to your GP or pharmacist first.
Six quick questions match you to the products in our range that fit your goal, with the reasons why.
