3 findings behind this formula. Hover a card for the detail and the source.
Glucosamine plus chondroitin improved total WOMAC knee scores versus placebo in a meta-analysis of adults with knee osteoarthritis.
Meta-analysis of 8 RCTs (3,793 patients); the combination improved total WOMAC score versus placebo (mean difference -12.0) and showed a small reduction in joint-space narrowing.
In a meta-analysis of 25 RCTs, chondroitin sulfate reduced knee pain and improved function versus placebo in knee osteoarthritis.
Meta-analysis of 25 placebo-controlled RCTs in knee osteoarthritis; chondroitin sulfate reduced pain and improved physical function, glucosamine sulfate reduced joint-space narrowing, and both were well tolerated.
Adding MSM to glucosamine and chondroitin improved knee pain and function scores more than placebo over 12 weeks in early knee osteoarthritis.
Double-blind RCT, 147 adults with grade I-II knee OA; 1,500 mg glucosamine + 1,200 mg chondroitin + 500 mg MSM daily for 12 weeks improved WOMAC and VAS pain scores versus placebo. Doses are higher than in this product.