A lactase (tilactase) supplement taken before lactose improved breath-test results and gut symptoms versus placebo in lactose-intolerant adults.
Randomised trial in 60 lactose-intolerant patients (20 per group); tilactase taken 15 minutes before lactose normalised breath tests more often and reduced peak hydrogen and symptom scores versus placebo.
Alpha-galactosidase (1,200 GalU) taken with a bean meal reduced gas production and flatulence in healthy volunteers.
Double-blind, placebo-controlled study in 8 healthy volunteers eating 420 g of beans; both 300 and 1,200 GalU lowered total symptom score, and 1,200 GalU also reduced breath hydrogen and flatulence severity.
Oral alpha-galactosidase reduced flatulence events after a high-fibre bean meal compared with placebo.
Double-blind crossover study in 19 adults eating meatless chilli; alpha-galactosidase significantly reduced flatulence events per hour over 6 hours compared with placebo.