Cayenne is a hot chilli pepper, a variety of Capsicum annuum, usually dried and ground into a fine red powder. Chillies originally come from Central and South America and spread around the world after the 1500s. Cayenne is named after the city of Cayenne in French Guiana.
Its heat comes from capsaicin and related compounds called capsaicinoids, which act on the same nerve receptors that sense heat, which is why chilli feels hot even though it does not raise the temperature of your mouth. Cayenne is a staple in cooking from Mexico to India and is traditionally used to support metabolism and circulation. Researchers have studied capsaicin and capsaicinoids in small trials, including on energy use, but the effects seen were small and capsaicin has no authorised health claim.
On labels you will see cayenne pepper, Capsicum annuum fruit powder, capsicum extract or capsaicinoids, sometimes with a heat rating in Scoville units or a capsaicin percentage. Some extracts are encapsulated to reduce stomach irritation.