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Nattokinase is an enzyme from natto, a fermented soybean food, studied for its role in normal circulation. A 2023 meta-analysis of six trials found a small average fall in blood pressure, but no cholesterol benefit, and a three-year trial found no effect on artery health. It may increase bleeding risk.

Coenzyme Q10 is a compound your body makes to help cells produce energy, and it also works as an antioxidant. Levels tend to fall with age, and statins can lower blood levels. Research on supplements for statin-related muscle aches and heart failure is mixed, so it suits some people more than others.

The main benefits of fish oil come from two omega-3 fats, EPA and DHA. Together they contribute to the normal function of the heart, and DHA contributes to normal brain function and vision, with a daily intake of 250 mg. Research on preventing heart disease is less clear, and oily fish remains the first choice.